Mannose-Binding Protein Deficiency

A condition characterized by a mannose-binding lectin (MBL) protein level of less than 100 ng/ml, that occurs in about 5% of people of European descent and in about 10% of sub-Saharan Africans. Most MBL-deficient adults appear healthy, but low levels of MBL are associated with increased risk of infection in toddlers, in cancer patients undergoing chemotherapy, and in organ-transplant patients receiving immunosuppressive drugs, particularly recipients of liver transplants. Polymorphisms in the MBL2 gene have been identified. OMIM: 614372

Also Known As:

MBL Deficiency; MBL2 Deficiency; MBP Deficiency; Mannose-Binding Lectin Deficiency; Mannose-Binding Lectin Protein Deficiency

Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 960
- Inborn Genetic Diseases: 12342
  - Inborn Errors Metabolism: 1183
    - Mannose-Binding Protein Deficiency: 188
Nutritional and Metabolic Diseases: 15
- Metabolic Diseases: 10634
  - Inborn Errors Metabolism: 1183
    - Mannose-Binding Protein Deficiency: 188
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Lectins: 6872
    - C-Type Lectins: 1018
      - Collectins: 148
        Mannose-Binding Lectin: 1392
        Mannose-Binding Protein Deficiency: 188
    - Mannose-Binding Lectins: 27
      - Mannose-Binding Lectin: 1392
        Mannose-Binding Protein Deficiency: 188

Francien C Fallaux van den Houten Selected Research

Francien C Fallaux van den Houten Research Topics

Disease

Drug/Important Bio-Agent (IBA)